Protein Details: Aquaporin-7
Protein ID
ICDB_Pro_0221
Protein Name
Aquaporin-7
Gene Name
Aqp7
Organism
Mus musculus (Mouse)
Length
303 amino acids
AlphaFoldDB
AF-O54794-F1-model_v4.pdb
Function
Forms a channel that mediates water and glycerol transport across cell membranes at neutral pH. The channel is also permeable to urea (By similarity). Plays an important role in body energy homeostasis under conditions that promote lipid catabolism;giving rise to glycerol and free fatty acids. Mediates glycerol export from adipocytes. After release into the blood stream;glycerol is used for gluconeogenesis in the liver to maintain normal blood glucose levels and prevent fasting hypoglycemia . Required for normal glycerol reabsorption in the kidney.
Sequence
PDB Structures
Ligand Binding
Binding Site
SITE 120: "Important for permeability to glycerol"
Disease
Colonic injury
Location
Detected in proximal tubules in kidney (PubMed:15998844;PubMed:17077387). Detected in the capillary network between muscle fibers in skeletal muscle and heart;and in spermatids and on spermatozoa tails in testis and epididymis (PubMed:17077387). Detected in white and brown adipose tissue;especially on small blood vessels (at protein level) (PubMed:15591341;PubMed:17077387;PubMed:25643985). Detected in white and brown adipose tissue;especially on small blood vessels (at protein level) (PubMed:15591341;PubMed:17077387;PubMed:25643985). Detected in white and brown adipose tissue;especially on small blood vessels (at protein level) (PubMed:15591341;PubMed:17077387;PubMed:25643985). Detected in kidney and white adipose tissue (PubMed:15746100)
DOI ID
10.1126/science.1112014; 10.1101/gr.2596504; 10.1016/j.cell.2010.12.001; 10.1073/pnas.0406230101; 10.1074/jbc.c500028200; 10.1152/ajprenal.00133.2005; 10.1073/pnas.0503291102; 10.1152/ajprenal.00314.2006; 10.1016/j.febslet.2015.01.025
RefSeq
NP_031499.1; XP_006537623.2